Medroxyprogesterone and weight gain. Common Questions and Answers about Medroxyprogesterone and weight gain. depo-provera. I went back on the medication Medroxyprogesterone this month. I was on it in March and started my period as normal but instead of lasting 14 days it lasted 12. Last month I forgot that I was suppose to take the medication and as normal I started but one day early and. If you only have to take this for 21 days once, you may gain some water weight, but should not gain much true weight. Since you are a bit concerned about the possible weight gain, cut back, way back on salt while you are taking it and make sure you have some healthy low calorie/low fat snacks available. While medroxyprogesterone 10 mg functions to regulate the menstrual cycles, it can temporarily alter menstruation in other ways. The medication can cause the woman to experience altered flow levels during menstruation. so far I have found that the only way to lose weight on seroquel is to also be on effexor xr. It is possible to lose weight on seroquel and not be taking any other drug. These hormones are associated with aging and aging absolutely affects one’s weight. Metabolism slows, hormone levels change, and vigorous activity becomes more difficult. Can Provera cause Weight Loss? Weight Loss is a known side effect of Provera. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Weight Loss is a known side effect of Provera. Common Questions and Answers about Medroxyprogesterone and weight loss depo-provera At that point, I would then do some blood work including prolactin, thyroid, fsh and lh levels. Although most people do not experience any problems with Provera ® (medroxyprogesterone acetate), certain problems may occur while taking this medicine. Some people who are prescribed this drug may wonder if Provera causes weight gain. Increase your fluid intake. Depo Provera may make your body retain water. This fluid retention, especially in the breasts, hips and thighs, can make women feel like they're gaining weight quickly, but the water retention should pass as your body adjusts to the medication. Getting Started With Depo-Provera Many women , however, do not gain weight when they use Depo, and some women will lose weight while using Depo.